Compositions comprising modafinil for treatment of fatigue...

Details Compositions comprising modafinil for treatment of fatigue... Compositions comprising modafinil for treatment of fatigue...

A - Human Necessities

61

K

A61K 31/165 (2006.01) A61P 25/28 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2689735

Modafinil is effective in improving symptoms of attention deficit hyperactivity disorder and symptoms of multiple sclerosis fatigue. The administration of modafinil is also shown to activate the tuberomamillary neurons of the posterior hypothalamus, and thus exhibits activity in an area of the brain associated with normal wakefulness functions. A method of identifying a compound that selectively modulates activity of the tuberomamillary nuclues of the posterior hypothalamus is also disclosed.

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