C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/00 (2006.01) A01N 43/04 (2006.01) A61K 31/573 (2006.01) A61K 39/00 (2006.01) A61K 39/38 (2006.01) C07K 14/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 17/00 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2408373
Synovial CRH functions in a paracrine manner to induce the nuclear transcription factor NURR1, which is abundantly expressed in the inflammatory cells of both rheumatoid arthritis and psoriatic arthritis synovium. This induction is suppressed by glucocorticoids. The invention is directed to the pivotal role the NURR subfamily of transcription factors play in modulation of peripheral CRH and CRH-mediated signaling through the CRH-receptor subtype R1.alpha., particularly in the inflammatory process in human arthritis.
La corticolibérine (CRH) synoviale permet, de manière endocrine, d'induire le facteur de transcription nucléaire NURR1, qui est abondamment exprimé dans les cellules inflammatoires à la fois de la synoviale de polyarthrite rhumatoïde et de la synoviale de rhumatisme psoriasique. Cette induction est supprimée par des glucocorticoïdes. Cette invention a trait au rôle essentiel que la sous-famille NURR des facteurs de transcription joue dans la modulation de la signalisation périphérique CRH et induite par CRH, par le sous-type R1.alpha. de récepteurs de CRH, notamment dans le processus inflammatoire de l'arthrite chez l'homme.
Bresnihan Barry
Conneely Orla M.
Fitzgerald Oliver
Murphy Evelyn
Baylor College Of Medicine
Borden Ladner Gervais Llp
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