Synthesis of acridine derivative multidrug-resistant inhibitors

Details Synthesis of acridine derivative multidrug-resistant inhibitors Synthesis of acridine derivative multidrug-resistant inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01)

Patent

CA 2289492

Synthesis of the MDRI of formula (I) from intermediates of acridone acid of formula (II) and aminophenethyl isoquinoline of formula (III), via steps including coupling and conversion to yield the MDRI of formula (I).

L'invention concerne la synthèse d'inhibiteurs résistant à de multiples médicaments présentant la formule (I), réalisés à partir d'intermédiaires de l'acide acridone selon la formule (II) et d'aminophénéthyle isoquinoline selon la formule (III). Les étapes de cette synthèse comprennent le couplage et la transformation pour produire les inhibiteurs de la formule (I).

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