Method to identify compounds to prevent neuron death

Details Method to identify compounds to prevent neuron death Method to identify compounds to prevent neuron death

G - Physics

01

N

G01N 33/68 (2006.01) C12Q 1/48 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2331680

The present invention describes methods for identifying compounds that inhibit JNK and MLK kinase activity as drugs for treating a mammal susceptible to or having a neurological condition. This invention also discloses methods for preventing neuronal cell death and treating neurological conditions that involve neuronal cell death, particularly neurodegenerative diseases characterized by glutamine or kainate mediated toxicity, such as Huntington's disease and Alzheimer's disease.

L'invention concerne des procédés permettant d'identifier des composés qui inhibent l'activité des kinases JNK et MLK, comme médicaments permettant de traiter un mammifère susceptible de souffrir de troubles neurologiques. L'invention concerne également des procédés permettant de prévenir la dégénérescence neuronale et de traiter les troubles neurologiques qui entraînent la dégénérescence neuronale, en particulier, les maladies neurodégénératives caractérisées par une toxicité provoquée par la glutamine ou le kaïnate, telles que la chorée de Huntington et la maladie d'Alzheimer.

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