Use of derivatives of aryl(or heteroaryl)azolylcarbinols in...

Details Use of derivatives of aryl(or heteroaryl)azolylcarbinols in... Use of derivatives of aryl(or heteroaryl)azolylcarbinols in...

A - Human Necessities

61

K

A61K 31/415 (2006.01) A61K 31/00 (2006.01) A61K 31/4155 (2006.01) A61K 31/454 (2006.01) A61K 31/5377 (2006.01) A61P 3/10 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 25/06 (2006.01)

Patent

CA 2332711

The derivatives of aryl(or heteroaryl)azolylcarbinol (I), in which R1 is an atom of hydrogen or a lower alkyl group; R2 is a dialkylaminoalkyl or azaheterocyclylalkyl radical; Ar is a phenyl or thienyl radical, optionally substituted; and Het is a heterocyclic five-membered azotic aromatic ring that contains from one to three nitrogen atoms, optionally substituted, are suitable for the treatment of neurogenic inflammation, present in different processes, such as diabetes, asthma, cystitis, gingivitis, migraine, dermatitis, rhinitis, psoriasis, inflammation of sciatic and lumbar nerves, gastrointestinal processes, ocular inflammation, etc., in mammals, including man.

L'invention concerne des dérivés d'aryl (ou hétéroaryl)azolylcarbinol de formule (I), dans laquelle R1 représente un atome d'hydrogène ou un groupe alkyle inférieur; R2 représente un radical dialkylaminoalkyle ou azahétérocyclylalkyle; Ar représente un radical phényle ou thiényle éventuellement substitué; et Het représente un hétérocycle aromatique azoté à 5 chaînons contenant entre un et trois atomes d'azote, éventuellement substitué. Ces dérivés conviennent au traitement de l'inflammation neurogène présente dans différentes pathologies, telles que le diabète, l'asthme, la cystite, la gingivite, la migraine, la dermatite, la rhinite, le psoriasis, l'inflammation des nerfs sciatiques et lombaires, les troubles gastro-intestinaux, l'inflammation oculaire, etc., chez les mammifères, y compris l'humain.

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