C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2724170
The present inventors demonstrate that the G-protein coupled receptor 55 (GPR55) is highly expressed in human aggressive breast cancer cells, and that the expression level may be correlated with the invasiveness and metastatic potential of these cells (for example metastasis to bone). In various aspects of the invention there are disclosed diagnostic tools or biomarkers that relate to the metastatic profile of breast cancer tumours. The invention also relates to pharmacological agents targeting this receptor for the purposes of inhibiting progression and spread of breast cancer.
Les présents inventeurs ont démontré que le récepteur 55 couplé aux protéines G (GPR55) est fortement exprimé dans des cellules de cancer du sein agressif humain et que le niveau d'expression peut être corrélé au pouvoir envahissant et au potentiel métastatique de ces cellules (par exemple la métastase vers les os). Dans divers aspects, l'invention porte sur des outils de diagnostic ou des biomarqueurs qui se rapportent au profil métastatique de tumeurs de cancer du sein. L'invention porte également sur des agents pharmacologiques ciblant ce récepteur à des fins d'inhibition de la progression et de la propagation d'un cancer du sein.
Ford Lesley Ann
Roelofs Anke Jozefien
Rogers Michael John
Ross Ruth Alexandra
Smart & Biggar
The University Court Of The University Of Aberdeen
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