C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/06 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07C 215/28 (2006.01) C07C 219/22 (2006.01) C07C 233/18 (2006.01) C07C 255/36 (2006.01) C07C 255/43 (2006.01) C07C 271/22 (2006.01) C07D 241/08 (2006.01) C07D 263/24 (2006.01) C07D 265/30 (2006.01) C07D 309/12 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 453/02 (2006.01) C07D 471
Patent
CA 2211668
The invention relates to compounds of the formula (see Formula 1) in which: - A is a divalent radical selected from: A1) -O-CO- A2) -CH2-O-CO- A3) -O-CH2-CO- A4) -O-CH2-CH2- A5) -N(R1)-CO- A6) -N(R1)-CO-CO- A7) -N(R1)-CH2-CH2- A8) -O-CH2- in which: - R1 is a hydrogen or a (Cl-C4)-alkyl; and - Het is a nitrogen-containing heterocycle. APPLICATION: Neurokinin receptor antagonists.
L'invention a pour objet des composés de formula (I) dans laquelle A représente un radical bivalent choisi parmi: A1)-O-CO-, A2)-CH2-O-CO-, A3)-O-CH2-CO-, A4)-O-CH2-CH2-, A5-N(R1)-CO-, A6)-N(R1)-CO-CO-, A7)-N(R1)-CH2-CH2-, A8)-O-CH2-, dans lesquels R1 représente un hydrogène ou un (C1-C4)alkyle, Am représente un hétérocyclique azoté. Application: antagonistes des récepteurs des neurokinines.
Emonds-Alt Xavier
Grossriether Isabelle
Gueule Patrick
Proietto Vincenzo
Van Broeck Didier
Sanofi
Sanofi-Aventis
Sim & Mcburney
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