Tissue-specific enhancer active in prostate

Details Tissue-specific enhancer active in prostate Tissue-specific enhancer active in prostate

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12N 15/11 (2006.01) C12N 15/57 (2006.01) C12N 15/85 (2006.01) C12N 15/861 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2181073

The invention provides a human prostate-specific transcriptional regulatory sequence, polylnucleotide comprising such regulatory regions, toxin gene constructs wherein a toxin gene is expressed under the transcriptional control of a human prostate-specific transcriptional regulatory sequence, and methods for treating prostate disease using such toxin gene constructs.

Cette invention concerne une séquence régulatoire transcriptionnelle humaine spécifique de la prostate, un polynucléotide comprenant lesdites régions régulatoires, des structures de gène de toxine dans lesquelles un gène de toxine est exprimé sous le contrôle transcriptionnel d'une séquence régulatoire transcriptionnelle humaine spécifique de la prostate, et des procédés de traitement des maladies de la prostate à l'aide de ces structures de gène de toxine.

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