Method to obtain microparticles containing a h+, k+-atp-ase...

Details Method to obtain microparticles containing a h+, k+-atp-ase... Method to obtain microparticles containing a h+, k+-atp-ase...

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61J 3/02 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2440158

A method for the preparation of homogeneous microparticles containing a H+,K+- ATPase inhibitor by a spray freezing technique characterized in that the medium to be atomized into droplets is having a high solid content and comprising besides the acid labile H+,K+-ATPaseinhibitor also a polymer and a liquid in whichthe polymer is soluble.

L'invention concerne un procédé de préparation de microparticules homogènes renfermant un inhibiteur de l'H?+¿,K?+¿-ATPase par une technique de congélation par pulvérisation. Ce procédé est caractérisé en ce que le milieu à pulvériser en gouttelettes présente une teneur élevée en matières solides et comporte, outre l'inhibiteur instable de décapage de l'H?+¿,K?+¿-ATPase, un polymère et un liquide dans lequel ce polymère est soluble.

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