Polypeptides and methods for thymic vaccination

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/06 (2006.01) A61K 39/00 (2006.01) C07K 7/06 (2006.01) C07K 14/145 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2392387

Methods of thymic vaccination are described, in which a polypeptide of interest is administered and which allows positive or negative selection of a T cell receptor (TCR) specificity in the thymus, to retain a desired specificity (positive) or to eliminate an undesired specificity (negative) at the level of TCR repertoire development, in order to generate TCRs which are designed to recognize disease antigens or foreign antigens, such as to treat or prevent cancers, autoimmune diseases, infections, or effects of biological warfare agents.

L'invention concerne des méthodes de vaccination thymique, dans lesquelles un polypeptide d'intérêt est administré et permet la sélection positive ou négative d'une spécificité du récepteur de l'antigène des lymphocytes TCR dans le thymus, de sorte qu'une spécificité (positive) voulue soit conservée ou qu'une spécificité indésirable (négative) soit éliminée au niveau de l'établissement du répertoire des caractères de TCR, que des TCR conçus pour reconnaître des antigènes de maladies ou des antigènes étrangers soient générés et que cela permette le traitement des cancers, des maladies auto-immunes, des infections ou des effets d'agents de guerre biologiques.

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