Medical devices having multiple charged layers

A - Human Necessities – 61 – L

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Details

A61L 31/10 (2006.01) A61L 27/34 (2006.01) A61L 27/54 (2006.01) A61L 29/08 (2006.01) A61L 29/16 (2006.01) A61L 31/16 (2006.01) A61K 31/337 (2006.01)

Patent

CA 2640592

According to an aspect of the present invention, medical devices are provided, which are adapted for implantation or insertion into a subject and which include at least one multilayer region that contains multiple charged layers of alternating charge. The multiple charged layers, in turn, include the following: (i) at least one charged block copolymer (e.g., a charged block copolymer that contains one or more polyelectrolyte blocks) and (ii) at least one charged therapeutic agent (e.g., a charged therapeutic agent that contains one or more polyelectrolyte blocks).

La présente invention concerne, selon un aspect, des dispositifs médicaux conçus pour une implantation ou une insertion dans un sujet et qui comprennent au moins une région à couches multiples qui contient des couches multiples chargées de charge alternée. Lesdites couches, tour à tour, comprennent ce qui suit : (i) au moins un copolymère séquencé chargé (par exemple, un copolymère séquencé chargé qui contient un ou plusieurs blocs polyélectrolytiques) et (ii) au moins un agent thérapeutique chargé (par exemple, un agent thérapeutique chargé qui contient un ou plusieurs blocs polyélectrolytiques).

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