Inhibition of inward sodium currents in cancer

Details Inhibition of inward sodium currents in cancer Inhibition of inward sodium currents in cancer

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/08 (2006.01) A61P 35/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) C07K 14/705 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2538754

Described is a constitutive inward Na+ currents found in a variety of human cancers. The constitutive inward Na+ current plays a role in increased cellular proliferation, cellular migration and volume regulation. The inward current is mediated, at least in part, by AISC-~ containing Na+ channels. In addition, an inhibitor of the inward current, the PcTX1 peptide, is described. Also provided are methods for screening compounds to inhibit the inward Na+ current, methods for screening for tumors expressing the inward Na+ current and methods for treating tumors expressing the inward Na+ current.

L'invention concerne des flux de Na?+¿ entrants constitutifs découverts dans divers cancers humains. Le flux de Na?+¿ entrant constitutif joue un rôle dans une prolifération cellulaire accrue, une migration cellulaire et une régulation de volume. La médiation dudit flux entrant est au moins partiellement assurée par des canaux de Na?+¿ contenant AISC. En outre, cette invention a trait à un inhibiteur du flux entrant, le peptide PcTX1, ainsi qu'à des méthodes de criblage de composés destinées à inhiber le flux de Na?+¿ entrant, à des méthodes de criblage de tumeurs exprimant le flux de Na?+¿ entrant et à des méthodes de traitement de tumeurs exprimant le flux de Na?+¿ entrant.

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