Modified plant viruses as vectors of heterologous peptides

Details Modified plant viruses as vectors of heterologous peptides Modified plant viruses as vectors of heterologous peptides

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 39/12 (2006.01) C07K 14/08 (2006.01) C07K 14/09 (2006.01) C07K 14/095 (2006.01) C07K 14/16 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12N 15/82 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2170412

The invention relates to assembled particles of a plant virus containing a foreign peptide insert in the coat protein of the virus. The site of the insert is free from direct sequence repeats flanking the insert. The invention also relates to a method of production of the particles and their use, in particular in vaccines.

L'invention concerne des particules assemblées d'un virus de végétal contenant un segment d'insertion de peptide étranger dans la protéine d'enveloppe du virus. Le site du segment d'insertion est exempt de répétitions de séquence directe encadrant l'insert. L'invention concerne également un procédé de production de ces particules ainsi que l'utilisation de celles-ci, notamment dans des vaccins.

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