Osteopontin-related compositions and methods

Details Osteopontin-related compositions and methods Osteopontin-related compositions and methods

A - Human Necessities

61

K

A61K 48/00 (2006.01) C07K 14/52 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2468020

This invention provides a method for reducing the amount of osteopontin in an osteopontin-expressing cell comprising introducing into the cell a nucleic acid which specifically inhibits osteopontin expression in the cell. This invention also provides methods for inhibiting the onset of, and treating, osteopontin-related disorders, as well as compositions for practicing the same. This invention further provides methods for determining the amount of osteopontin in a sample, and a kit for practicing the same. This invention also provides methods for determining whether an agent reduces the amount of osteopontin in an osteopontin-expressing cell. Finally, this invention provides methods for treating a subject afflicted with a disorder mediated by an endogenous protein.

L'invention concerne une méthode permettant de réduire la quantité d'ostéopontine exprimée dans une cellule, qui consiste à introduire dans ladite cellule un acide nucléique qui inhibe spécifiquement l'expression d'ostéopontine. L'invention concerne également des méthodes permettant d'inhiber l'apparition de troubles associés à l'ostéopontine et de les traiter, ainsi que des compositions permettant de mettre en oeuvre lesdites méthodes. L'invention concerne en outre des méthodes permettant de déterminer la quantité d'ostéopontine dans un échantillon, et un kit permettant de mettre en oeuvre lesdites méthodes. L'invention concerne de plus des méthodes permettant de déterminer le moment où un agent réduit la quantité d'ostéopontine exprimée dans une cellule. L'invention concerne enfin des méthodes permettant de traiter un sujet souffrant d'un trouble associé à une protéine endogène.

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