Method for inducing differentiation and/or proliferating...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2520830

It is intended to provide a method of inducing the differentiation and/or promoting the proliferation of regulatory T cells; a method of inhibiting vessel flow-mediated endothelial cell migration of immune cells; immunosuppression methods using these methods; and a medicinal composition to be used in these methods. Namely, a method of inducing the differentiation and/or promoting the proliferation of regulatory T cells by treating CD52- expressing T cells with a CD52 agonist containing anti-CD52 antibody, a method of inhibiting vessel flow-mediated endothelial cell migration of immune cells, and immunosuppression methods using these methods.

L'invention concerne une méthode d'induction de la différenciation et/ou de la facilitation de la prolifération de cellules T régulatrices. L'invention concerne également une méthode d'inhibition de la migration cellulaire endothéliale médiée par l'écoulement vasculaire de cellules immunitaires; des méthodes d'immunosuppression faisant appel à ces méthodes; et une composition médicinale à utiliser dans ces méthodes. L'invention concerne une méthode d'induction de la différenciation et/ou de la facilitation de la prolifération de cellules T régulatrices, par le traitement de cellules T d'expression CD52 par un agoniste de CD52 contenant un anticorps anti-CD52. L'invention concerne une méthode d'inhibition de la migration cellulaire endothéliale médiée par l'écoulement vasculaire de cellules immunitaires, et des méthodes d'immunosuppression faisant appel aux méthodes susmentionnées.

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