Atg-1120 (aif-1-delta), a novel splice variant of aif-1/rc-9

Details Atg-1120 (aif-1-delta), a novel splice variant of aif-1/rc-9 Atg-1120 (aif-1-delta), a novel splice variant of aif-1/rc-9

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2221688

ATG-1120 (AIF-1-delta) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ATG-1120 (AIF-1-delta) polypeptides and polynucleotides in the design of protocols for the treatment of atherosclerosis, CHF, restenosis, myocardial ischemia, hypertension, fibrotic vasculopathies (diabetes, SLE, AS), cerebrovascular events (e.g. stroke), hematopoietic disorders, ARDS, cancer (particularly leukemias), autoimmune diseases (e.g. HIV-infection and AIDS), fibroproliferative disorders (e.g. psoriasis), inflammatory disease (e.g. RA, Crohn's, IBS), glomerulopathies and disease states, both cardiovascular and non-cardiovascular, which are characterized by aberrant fibroproliferative/inflammatory response, among others, and diagnostic assays for such conditions.

Polypeptides et polynucléotides ATG-1120 (AIF-1-delta) et méthodes pour produire ces polypeptides par les techniques d'ADN recombinant. Sont également décrites des méthodes pour utiliser les polypeptides et polynucléotides ATG-1120 (AIF-1-delta) dans la conception de protocoles pour traiter l'athérosclérose, les défaillances cardiaques, la resténose, l'ischémie myocardique, l'hypertension, les vasculopathies fibreuses (le diabète, le lupus érythémateux disséminé, l'artériosclérose), les accidents vasculaires cérébraux, les troubles hématopoïétiques, le SDRA, le cancer (en particulier les leucémies), les maladies autoimmunes (p. ex. l'infection à VIH et le sida), les troubles fibroprolifératifs (p. ex. le psoriasis), les maladies inflammatoires (p. ex. la polyarthrite rhumatoïde, la maladie de Crohn, le syndrome du côlon irritable), les glomérulopathies et les états pathologiques, cardiovasculaires et non cardiovasculaires, caractérisés par une réponse fibroproliférative et inflammatoire aberrante, entre autres affections, de même que des épreuves diagnostiques permettant de déceler ces affections.

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