Antibodies directed to parathyroid hormone (pth) and uses...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/26 (2006.01) A61K 39/395 (2006.01) A61P 5/18 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2535156

Embodiments of the invention described herein relate to antibodies directed to the antigen parathyroid hormone (PTH) and uses of such antibodies. In particular, in some embodiments, there are provided fully human monoclonal antibodies directed to the antigen PTH. In further embodiments, nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided.

Dans certains modes de réalisation, la présente invention a trait à des anticorps dirigés vers l'hormone parathyroïde antigénique et les utilisations de tels anticorps. En particulier, dans certains modes de réalisation, il est prévu des anticorps dirigés vers l'hormone parathyroïde antigénique. Dans d'autres modes de réalisation, des séquences nucléotidiques codant pour, et des séquences d'acides aminés comportant, des molécules d'immunoglobuline à chaîne lourde et légère, notamment des séquences correspondant à des séquences à chaîne lourde et légère contiguës recouvrant les régions de cadres et/ou des régions déterminant la complémentarité (CDR), spécifiquement de la région de cadre 1 à la région de cadre 4 ou de la région déterminant la complémentarité 1 à la région déterminant la complémentarité 3, sont prévus.

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