A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/381 (2006.01) A61K 31/437 (2006.01) A61K 31/444 (2006.01) A61K 31/4725 (2006.01) A61K 31/485 (2006.01) A61K 31/498 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) A61P 25/04 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2666925
The present invention provides synergistic combinations for the treatment of conditions associated with pain including acute pain, e.g., postoperative pain, chronic pain, inflammatory pain, neuropathic pain and pain associated with migraine. In particular, the present invention relates to the use of an allosteric adenosine A1 receptor enhancer in conjunction with opioid analgesics or 2-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA)/kainate antagonists for alleviating pain, e.g., postoperative pain.
L'invention concerne des combinaisons synergiques destinées au traitement d'affections associées à une douleur, notamment une douleur aiguë, par exemple la douleur postopératoire, la douleur chronique, la douleur inflammatoire, la douleur neuropathique et la douleur associée à la migraine. L'invention concerne en particulier l'utilisation d'un activateur de récepteur allostérique d'adénosine A1 combiné à des analgésiques opioïdes ou de l'acide 2-amino-3-hydroxy-5-méthyl-4-isoxazole-propionique (AMPA)/des antagonistes de kaïnate, pour soulager la douleur, notamment la douleur postopératoire.
Eisenach James Conrad
King Pharmaceuticals Research And Development Inc.
Smart & Biggar
LandOfFree
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