Kidney-specific urate transporter and uses thereof

Details Kidney-specific urate transporter and uses thereof Kidney-specific urate transporter and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2456172

It is intended to identify and provide a novel urate transporter gene participating in the urate transport in the kidney and a urate transporter which is a polypeptide encoded by the above gene. Namely, a protein comprising the amino acid sequence represented by SEQ ID NO:1 or an amino acid sequence derived therefrom by deletion, substitution or addition of one to several amino acids and being capable of transporting uric acid and its analogs; and a gene encoding this protein.

L'invention concerne un nouveau gène de transporteur d'urate participant au transport de l'urate dans le rein, l'identification de ce gène et un transporteur d'urate qui est un polypeptide codé par ledit gène. Elle concerne notamment une protéine comprenant la séquence d'acides aminés représentée par SEQ ID NO :1 ou une séquence d'acides aminés dérivée de celle-ci, obtenue par délétion, substitution ou addition d'un ou de plusieurs acides aminés, et qui est capable de transporter l'acide urique et ses analogues ; et un gène codant pour cette protéine.

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