Map3ks as modifiers of the p53 pathway and methods of use

Details Map3ks as modifiers of the p53 pathway and methods of use Map3ks as modifiers of the p53 pathway and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 38/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) C12Q 1/527 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2449479

Human MAP3K genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MAP3K are provided.

On a identifié des gènes MAP3K humains en tant que modulateurs de la voie p53, ces derniers étant donc des cibles thérapeutiques pour les troubles associés à un dysfonctionnement de p53. Cette invention concerne également des méthodes d'identification de modulateurs de p53, comprenant le criblage d'agents qui modulent l'activité de MAP3K.

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