Fused pyrimidine derivates as rho-kinase inhibitors

Details Fused pyrimidine derivates as rho-kinase inhibitors Fused pyrimidine derivates as rho-kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2472619

Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

L'invention concerne des composés et des dérivés de ceux-ci, la synthèse et l'utilisation de ceux-ci comme inhibiteurs de la Rho-kinase. Ces composés sont utiles aux fins d'inhibition de croissance tumorale et aux fins de traitement de dysfonction érectile et d'autres indications induites par la Rho-kinase, par exemple, une coronaropathie.

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