Inducing immune responses to influenza virus using...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) A61K 39/00 (2006.01) A61K 39/145 (2006.01) A61P 37/04 (2006.01) C07K 7/08 (2006.01) C07K 14/11 (2006.01) C07K 19/00 (2006.01) C12N 15/44 (2006.01)

Patent

CA 2657849

The present invention provides polynucleotides and polypeptides capable of enhancing the immune response of a human in need of protection against influenza virus infection by administering in vivo, into a tissue of the human, at least one polynucleotide comprising one or more regions of nucleic acid encoding an influenza protein or a fragment, variant, or derivative thereof, or at least one polypeptide encoded therefrom. The present invention also relates to identifying and preparing influenza virus epitopes and to polynucleotides and polypeptides comprising such influenza virus epitopes. The present invention also relates to compositions and methods of use in the prevention and treatment of influenza virus infection.

La présente invention concerne des polynucléotides et des polypeptides capables d'améliorer la réponse immunitaire d'un être humain ayant besoin d'une protection contre une infection par le virus de la grippe en administrant in vivo, dans un tissu de l'être humain, d'au moins un polynucléotide comprenant une ou plusieurs régions d'un acide nucléique qui code une protéine de la grippe ou un fragment, une variante, ou un dérivé de celle-ci, ou au moins un polypeptide codé à partir de celui-ci. La présente invention concerne également l'identification et la préparation d'épitopes du virus de la grippe et des polynucléotides et des polypeptides comprenant ces épitopes du virus de la grippe. La présente invention concerne aussi des compositions et des procédés d'utilisation dans le cadre de la prévention et du traitement d'une infection par le virus de la grippe.

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