C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 31/513 (2006.01) A61K 31/7032 (2006.01) A61K 31/727 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/47 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 14/00 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2521469
Disclosed are compositions relating to the Nogo receptor (NgR) family as well as fragments, chimeras, and variants thereof. The invention provides polypeptides, nucleic acids, vectors, expression systems, and antibodies and antibody fragments related to the NgRs as well as uses thereof. Such uses include modulation neurite outgrowth in a subject and treatment of central nervous system disorders in a subject, as well as, methods of identifying and screening compounds that can be used for modulating neurite outgrowth in a subject or in treatment of central nervous system disorders in a subject.
L'invention concerne des compositions liées à la famille des récepteurs Nogo (NgR) ainsi que des fragments, des chimères et des variantes génétiques de ceux-ci. L'invention concerne des polypeptides, des acides nucléiques, des vecteurs, des systèmes d'expression, des anticorps et des fragments d'anticorps liés aux NgR ainsi que des applications de ceux-ci. Ces applications comprennent la modulation de la formation de neurites chez un sujet et le traitement de troubles du système nerveux central chez un sujet, ainsi que des procédés d'identification et de criblage de composés pouvant servir à moduler la formation de neurites chez un sujet, ou à traiter des troubles du système nerveux central chez un sujet.
Gowling Lafleur Henderson Llp
University Of Rochester
LandOfFree
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