Novel polymorphic forms of sunitinib base

Details Novel polymorphic forms of sunitinib base Novel polymorphic forms of sunitinib base

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01)

Patent

CA 2720943

The present invention relates to novel polymorphic forms of N-[2- (diethylamino)ethyl]-5-[(5-fluoro-1,2- dihydro-2-oxo-3H-indol-3-ylidene)methyl-2,4-dimethyl-1H-pyrrole-3-carboxamide- Sunitinib base (I). The present invention also relates to methods of preparing such polymorphic crystals.

La présente invention porte sur de nouvelles formes polymorphes du N-[2-(diéthylamino)éthyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidène)méthyl-2,4-diméthyl-1H-pyrrole-3-carboxamide-sunitinib base (I). La présente invention porte également sur des procédés de fabrication de tels cristaux polymorphes.

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