Nanoparticulate quinazoline derivative formulations

Details Nanoparticulate quinazoline derivative formulations Nanoparticulate quinazoline derivative formulations

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 31/517 (2006.01)

Patent

CA 2604735

The present invention is directed to nanop articulate quinazoline derivative compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The nanoparticulate quinazoline derivative particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the treatment of hyperproliferative disorders, such as cancer and other neoplastic diseases. The compositions may include quinazomiamine derivatives such as erlotinib or a salt thereof.

La présente invention a pour objet des préparations de nanoparticules des dérivés de quinazoline dont les profils pharmacocinétiques sont améliorés et pour lesquelles la variabilité après repas/à jeun est réduite. Les nanoparticules de dérivés de quinazoline de la préparation présentent une granulométrie moyenne effective inférieure à environ 2000 nm et peuvent être employés dans le traitement de troubles hyperproliférants, tels que le cancer et d'autres maladies néoplasiques. Les préparations peuvent inclure des dérivés de quinazomiamine comme l'erlotinib ou un sel de ce composé.

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