C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2331880
Novel BPI deletion analogs are provided that consist of amino acid residues (10 through 193) of mature human BPI wherein the cysteine residue at BPI amino acid position (132) is replaced by another amino acid. Fusion proteins comprising these analogs are also provided, as are polynucleotides encoding these products, materials and methods for their recombinant production, compositions and medicaments of these products, and therapeutic uses for these products.
L'invention concerne de nouveaux analogues de délétion de la protéine bactéricide/augmentant la perméabilité (BPI), constitués des restes d'acides aminés (10 à 193) d'une BPI humaine mature, dans lesquels le reste de cystéine en position (132) de l'acide aminé de la BPI est remplacé par un autre acide aminé. L'invention concerne également les protéines de fusion comprenant ces analogues, ainsi que les polynucléotides codant pour ceux-ci, des substances et des techniques de production par recombinaison, des compositions et des médicaments à base de ces analogues, et leurs utilisations thérapeutiques.
Burke David
Carroll Stephen Fitzhugh
Horwitz Arnold
Mbm Intellectual Property Law Llp
Xoma Technology Ltd.
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