Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl...

Details Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl... Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl...

C - Chemistry, Metallurgy

07

D

C07D 233/54 (2006.01) A61K 31/415 (2006.01) C07D 233/68 (2006.01) C07D 235/06 (2006.01) C07D 235/14 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2136838

2136838 9404508 PCTABS00030 Compounds characterized generally as imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of formula (I), wherein A is selected from CO and SO2; wherein X is selected from oxygen atom and methylene; wherein B is selected from imidazolyl and benzimidazolyl groups; wherein R1 is selected from hydrido, methyl, ethyl, isopropyl and n-propyl; wherein R2 is phenylmethyl; wherein each of R3 and R5 is hydrido; wherein R4 is selected from (.alpha.), wherein V is selected from hybrido and methyl; wherein R6 is cyclohexylmethyl; wherein R7 is selected from isobutyl, cyclopropyl and cyclopropylmethyl; wherein q is a number selected from zero through three, inclusive; and wherein n is a number selected from zero through three, inclusive; or a pharmaceutically-acceptable salt thereof.

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