Aminoalcohol derivatives

Details Aminoalcohol derivatives Aminoalcohol derivatives

C - Chemistry, Metallurgy

07

C

C07C 229/56 (2006.01) A61K 31/18 (2006.01) A61K 31/195 (2006.01) A61K 31/325 (2006.01) A61K 31/4425 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 13/10 (2006.01) C07C 229/38 (2006.01) C07C 271/16 (2006.01) C07C 311/51 (2006.01) C07C 323/63 (2006.01) C07D 213/38 (2006.01) C07D 213/61 (2006.01)

Patent

CA 2551167

The present invention relates to a compound formula (I): wherein (II) is (III) or (IV), X is bond, -CH2-, -O- or -NH-, R1 and R12 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or optionally substituted lower alkyl, R3 is hydrogen or an amino protective group, R4, R5 and R6 are each independently hydrogen or optionally substituted lower alkyl, R7 is -Z- R13, in which Z is bond, etc., and R13 is carboxy, lower alkoxycarbonyl, (lower alkylsulfonyl) carbamoyl or lower alkanoylsulfamoyl, R8 is -Y-R9, in which Y is bond, -CH2-, -O-, -S-, etc., and R9 is hydrogen, lower alkyl, cyclo (lower) alkyl, etc., and R11 is hydrogen, lower alkyl, lower alkoxy, etc., or a salt thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.

L'invention porte sur un composé (ou l'un de ses sels) de formule (I) dans laquelle: (II) est (III) ou (IV), X est une liaison, -CH¿2?-, -O- ou -NH-, R?1¿ et R?12¿ sont chacun indépendamment hydrogène, halogène, alkyle inférieur, etc., R?2¿ est hydrogène ou alkyle inférieur facultativement substitué, R?3¿ est hydrogène ou un groupe amino protecteur, R?4¿, R?5¿ and R?6¿ sont chacun indépendamment hydrogène ou alkyle inférieur facultativement substitué, R?7¿ est -Z-R?13¿, dans lequel Z est une liaison, etc. et R?13¿ est carboxy, alkoxycarbonyle inférieur, (alkylsulfonyl inférieur) carbamoyle ou alkanoylsulfamoyle inférieur, R?8¿ est -Y-R?9¿, où Y une liaison, -CH¿2?-, -O-, -S-, etc., et R?9¿ est hydrogène, alkyle inférieur, cyclo alkyle inférieur, etc., et R?11¿ est hydrogène, alkyle inférieur, alkoxy inférieur, etc. Ledit composé (I) et ses sels pharmacocompatibles s'avèrent utiles pour des traitements prophylactiques et/ou thérapeutiques de l'urée de Pollaki ou de l'incontinence urinaire.

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