Detection methods for disorders of the lung

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2528572

The present invention is directed to prognostic and diagnostic methods to assess lung disease risk caused by airway pollutants by analyzing expression of one or more genes belonging to the airway transcriptome provided herein. Based on the finding of a so called "field defect" affecting the airways, the invention further provides a minimally invasive sample procurement method in combination with the gene expression-based tools for the diagnosis and prognosis of diseases of the lung, particularly diagnosis and prognosis of lung cancer.

La présente invention concerne des méthodes de pronostic et de diagnostic destinées à évaluer le risque de développer une maladie pulmonaire liée à la présence de polluants dans les voies respiratoires. Ces méthodes consistent à analyser l'expression d'un ou plusieurs gènes appartenant au transcriptome des cellules des voies respiratoires. Sur la base de la découverte d'un "effet de champ" affectant les voies respiratoires, l'invention concerne une méthode de prélèvement d'échantillon faiblement invasive en combinaison avec des outils basés sur l'expression génique pour le diagnostic et le pronostic de maladies pulmonaires, et notamment pour le diagnostic et le pronostic du cancer du poumon.

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