Method of identifying compounds useful to treat neuronal...

C - Chemistry – Metallurgy – 12 – N

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C12N 9/14 (2006.01) A61K 31/12 (2006.01) A61K 36/00 (2006.01) A61P 25/28 (2006.01) C12Q 1/26 (2006.01) C12Q 1/34 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2634670

Methods of identifying agents that inhibit ROS by altering the binding of a GTPase such as Rac to SOD, agents identified by the method, and methods of using compounds that inhibit ROS to inhibit or treat neuronal degenerative diseases, are provided.

La présente invention concerne des procédés d'identification d'agents inhibiteurs d'espèces réactives de l'oxygène par la modification de la liaison d'une GTPase telle que Rac à la dismutase superoxyde, des agents identifiés par ce procédé, et des procédés d'utilisation de composés inhibiteurs d'espèces réactives de l'oxygène pour la prévention ou de traitement de maladies dégénératives neuronales.

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