A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 7/18 (2006.01) C07K 16/00 (2006.01) C07K 16/08 (2006.01) C07K 16/12 (2006.01) C07K 16/20 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C12N 5/12 (2006.01) C12N 15/13 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2309990
The invention relates to modified immunoglobulin molecules in which one or more variable region residues that form intrachain disulfide bonds are substituted with amino acid residues that do not contain sulfydryl groups, such that the intrachain disulfide bond does not form. Such immunoglobulin molecules have an enhanced ability to elicit an anti-idiotype response. The invention further provides for the methods of prevention and treatment of cancer and/or infectious diseases using the modified immunoglobulins of the invention.
L'invention concerne des molécules d'immunoglobuline modifiées dans lesquelles un ou plusieurs restes de la partie variable formant des liaisons disulfure inter-chaînes sont substitués par des restes d'aminoacide ne renfermant pas de groupes sulfydryle, de manière que la liaison disulfure inter-chaînes ne se forme pas. De telles molécules d'immunoglobuline présentent une capacité améliorée à déclencher une réponse anti-idiotype. L'invention concerne également des procédés de prévention et de traitement du cancer et/ou des maladies infectieuses faisant intervenir les immunoglobulines modifiées de l'invention.
Euro-Celtique S.a.
Osler Hoskin & Harcourt Llp
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