Modulation of human sodium channels in dorsal root ganglia

Details Modulation of human sodium channels in dorsal root ganglia Modulation of human sodium channels in dorsal root ganglia

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) A61P 23/00 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2379391

A novel human tetrodotoxin resistant sodium channel is described, along with isolated nucleic acid molecules that encode this channel. Methods for identifying agents that modulate the Na+ current through the channel are provided, as well as related therapeutic and diagnostic methods.

L'invention concerne un nouveau canal sodique résistant à la tétrodotoxine humaine, ainsi que des molécules d'acide nucléique codant pour ce canal. L'invention concerne également des méthodes de détermination d'agents modulant le courant Na?+¿ dans le canal, ainsi que des méthodes thérapeutiques et diagnostiques afférentes.

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