C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/14 (2006.01) A61K 31/55 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2756809
The present invention relates to substituted tetrahydropyrazolo-pyrido-azepine compounds of formula (I) and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof, or a pharmaceutically acceptable salt or ester thereof, wherein: X1, X2; and X3, together with the two carbon atoms numbered "1" and "2", form a ring selected from (a), (b) and (c).
La présente invention porte sur des composés tétrahydropyrazolo-pyrido-azépine substitués de formule (I) et sur des procédés de synthèse de ces composés. La présente invention porte également sur des compositions pharmaceutiques contenant des composés tétrahydropyrazolo-pyrido-azépine substitués et sur des procédés de traitement de troubles prolifératifs cellulaires, tels que le cancer, par administration de ces composés et de ces compositions pharmaceutiques à des sujets en ayant besoin, ou sur un sel ou ester pharmaceutiquement acceptable de ceux-ci, dans lesquels : X1, X2 et X3, conjointement avec les deux atomes de carbone numérotés « 1 » et « 2 », forment un noyau choisi parmi (a), (b) et (c).
Lapierre Jean-Marc
Link Jeffrey S.
Namdev Nivedita
Yang Rui-Yang
Arqule Inc.
Ridout & Maybee Llp
LandOfFree
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