C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) C07K 14/00 (2006.01) C07K 14/775 (2006.01)
Patent
CA 2727465
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.
Famille de polypeptides à occurrence non naturelle ayant une activité d'efflux de choplestérol qui est semblable à celle des apolipoprotéines pleine longueur (par exemple, Apo AI et Apo E), et ayant une sélectivité élevée vis-à-vis d'ABAC1 qui est semblable à celle des apolipoprotéines pleine longueur. Egalement, compositions comprenant de tels polypeptides, procédés d'identification, d'analyse et de synthèse de ces polypeptides, et procédés de traitement, de prévention ou de diagnostic de maladies et de troubles associés à la dyslipidémie, l'hypercholestérolémie et l'inflammation.
Bielicki John K.
Johansson Jan
Smart & Biggar
The Regents Of The University Of California
LandOfFree
Improved peptide mediators of cholesterol efflux does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Improved peptide mediators of cholesterol efflux, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Improved peptide mediators of cholesterol efflux will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1760109