Peptide fragments having cell death inhibitory activity

Details Peptide fragments having cell death inhibitory activity Peptide fragments having cell death inhibitory activity

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) C12N 5/071 (2010.01) A61K 38/17 (2006.01) C07K 16/18 (2006.01) C12N 5/16 (2006.01)

Patent

CA 2351558

The present invention provides a peptide fragment or a series of peptide fragments having a cell death--inhibitory activity, having the amino acid sequence consisting of 103 amino acid residues at the C-terminal of selenoprotein P, or having said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or having a partial sequence of either of the above amino acid sequences, a medicament for treatment comprising said peptide fragment or a series of peptide fragments, an antibody to said peptide fragment or a series of peptide fragments, and a method for screening a cell death-inhibitory activity using said peptide fragment or a series of peptide fragments. The preferable peptide fragment or a series of peptide fragments of the present invention has the amino acid sequences shown in SEQ ID NO: 1 and/or SEQ ID NO: 2 or has a partial sequence thereof.

L'invention concerne des fragments peptidiques qui inhibent la mort cellulaire et qui contiennent la séquence d'acide aminé constituée de 103 résidus d'acide aminé sur l'extrémité C-terminale de la sélénoprotéine P, une séquence d'acide aminé dérivée de cette première séquence d'acide aminé par délétion, substitution ou addition d'un ou de plusieurs acides aminés. L'invention concerne également des médicaments contenant lesdits fragments peptidiques. L'invention concerne en outre des anticorps contre lesdits fragments peptidiques. De préférence, les exemples des fragments peptidiques sont ceux contenant les séquences d'acide aminé représentées par SEQ ID NO:1 et/ou deux séquences ou des séquences partielles desdites séquences d'acide aminé.

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