Hiv protease inhibitors with an internal lactam ring

Details Hiv protease inhibitors with an internal lactam ring Hiv protease inhibitors with an internal lactam ring

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) C07D 207/27 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/00 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07F 9/547 (2006.01)

Patent

CA 2084800

147/RDM78 146/RDM79 18416 TITLE OF THE INVENTION HIV PROTEASE INHIBITORS WITH AN INTERNAL LACTAM RING ABSTRACT OF THE DISCLOSURE Compounds of the form, A-B-G-J wherein A is an amine protecting group and the like, B an amino acid or analog thereof, G a dipeptide isostere having an internal lactam ring, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, 147/RDM78 146/RDM79 - ii - 18416 pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

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