Topical compositions for prostaglandin e1 delivery

Details Topical compositions for prostaglandin e1 delivery Topical compositions for prostaglandin e1 delivery

A - Human Necessities

61

K

A61K 9/06 (2006.01) A61F 13/00 (2006.01) A61K 9/00 (2006.01) A61K 9/70 (2006.01) A61K 31/557 (2006.01) A61K 31/5575 (2006.01) A61K 47/00 (2006.01) A61K 47/14 (2006.01) A61K 47/18 (2006.01) A61K 47/36 (2006.01) A61L 15/00 (2006.01)

Patent

CA 2309165

A topical composition of a semi-solid consistency suitable is provided for transdermal application of prostaglandin E1. The composition comprises prostaglandin E1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl-2- (N,N-disubstituted amino)-alkanoate ester, an (N,N-disubstituted amino)- alkanol alkanoate, or a mixture of these. The lipophilic compound may be an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.

L'invention concerne une composition topique à consistance pâteuse utile pour l'application transdermique de prostaglandine E¿1?. La composition renferme de la prostaglandine E¿1?, un activateur de pénétration, une gomme de polysaccharide, un composé lipophile et un système de tampon acide. L'activateur de pénétration est un ester d'alkyl-2-(amino N,N-disubstitué)-alcanoate, un (amino N,N-disubstitué)-alcanol alcanoate ou un mélange de ceux-ci. Le composé lipophile peut être un alcool C¿1? à C¿8? aliphatique, un ester C¿8? à C¿30? aliphatique ou un mélange de ceux-ci. La composition comporte un système de tampon susceptible de conférer une valeur de pH tamponné à ladite composition de l'ordre d'environ 3 à environ 7,4.

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