C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/40 (2006.01) A61K 31/70 (2006.01) A61K 39/12 (2006.01) C07K 14/18 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01)
Patent
CA 2398872
Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural protein genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
L'invention porte sur des flavivirus chimériques avirulents et immunogènes, élaborés de manière à présenter des mutations d'acides aminés dans les protéines non structurelles d'un flavivirus. Les virus chimériques contenant les gènes non structurels atténués par mutation du virus forment un squelette dans lequel sont insérés les gènes des protéines structurelles d'une deuxième souche de flavivirus. Ces virus chimériques provoquent une puissante immunogénicité, non accompagnée des symptômes cliniques des maladies virales. Les virus chimériques atténués sont efficaces comme immunogènes ou comme vaccins, ou peuvent être intégrés à une préparation pharmaceutique conférant une immunité simultanée contre plusieurs souches de flavivirus pathogènes.
Bhamarapravati Natth
Butrapet Siritorn
Gubler Duane J.
Kinney Claire Y. H.
Kinney Richard M.
Gowling Lafleur Henderson Llp
Mahidol University
The Government Of The United States Of America As Represented By Department Of Health And Human Services
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