Novel benzothiazine and benzothiadiazine derivatives, method...

Details Novel benzothiazine and benzothiadiazine derivatives, method... Novel benzothiazine and benzothiadiazine derivatives, method...

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/5415 (2006.01) A61K 31/549 (2006.01) A61P 25/00 (2006.01) C07D 209/00 (2006.01) C07D 279/02 (2006.01) C07D 285/00 (2006.01)

Patent

CA 2471120

The invention concerns a compound of formula (I), wherein: R¿1? represents an aryl or heteroaryl; R¿2? represents hydrogen, halogen or a hydroxy; X represents oxygen or sulphur; Y represents oxygen, sulphur or NR wherein R represents hydrogen or an alkyl; A represents CR¿4?R¿5? or NR¿4?; R¿3? represents hydrogen, alkyl or cycloalkyl; R¿4? represents hydrogen or alkyl; or A represents nitrogen and forms with adjacent -CHR¿3?-the cycle (a) wherein m represents 1, 2, or 3, R¿3? represents hydrogen or halogen; their isomers and their addition salts. Said compounds are useful as medicines, as AMPA modulators.

Composé de formule (1) : dans laquelle R1 représente un aryle ou hétéroaryle, R2représente un hydrogène, halogène ou un hydroxy, X représente un oxygène ou soufre, Y représente un oxygène, soufre ou NR dans lequel R représente un hydrogène ou un alkyle, A représente CR4R5 ou NR4, R3 représente un hydrogène, alkyle ou cycloalkyle, R4 représente un hydrogène ou alkyle, ou bien A représente un azote et forme avec -CHR3- adjacent le cycle dans lequel m représente 1, 2 ou 3, R5 représente un hydrogène ou halogène, leurs isomères ainsi que leurs sels d'addition. Médicaments, comme modulateurs AMPA.

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