Tim-3 polypeptides

Details Tim-3 polypeptides Tim-3 polypeptides

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 31/713 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 37/02 (2006.01) C07H 21/00 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2541006

The invention relates to isolated polypeptides and acids encoding polypeptides which comprise a tim-3 IgV domain and a tim-3 intracellular domain, wherein the polypeptides do not comprise a tim-3 mucin domain or a tim-3 transmembrane domain. In addition, the invention relates to methods of modulating immune responses in a subject, comprising administering to the subject a therapeutically effective amount of an agent that modulates tim-3 activity. Immune responses include, but are not limited to, immune tolerance, transplantation tolerance, Th1 responses and Th2 responses.

L'invention concerne des polypeptides isolés et des acides nucléiques codant pour les polypeptides, comprenant un domaine IgV de tim-3 et un domaine intracellulaire de tim-3. Ces polypeptides ne comprennent pas de domaine mucine de tim-3 ou un domaine transmembranaire de tim-3. Par ailleurs, l'invention porte sur des méthodes de modulation de réponses immunitaires chez un sujet, qui consistent à administrer au sujet une quantité efficace au plan thérapeutique d'un agent qui module l'activité de tim-3. Les réponses immunitaires englobent, entre autres, la tolérance immunitaire, les réponses de Th1 et les réponses de Th2.

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