Vaccine containing a peroxiredoxin and/or a .beta.-tubulin

Details Vaccine containing a peroxiredoxin and/or a .beta.-tubulin Vaccine containing a peroxiredoxin and/or a .beta.-tubulin

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 14/435 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2256710

The present application relates to vaccine compositions comprising peroxiredoxin and/or .beta.-tubulin antigenic material, preferably of Fasciola or Dicrocoelium origin, for use in combatting a parasitic infestation of helminths in a mammal. It further relates to nucleic acid sequences which encode peroxiredoxin and/or .beta.-tubulin molecules and the amino-acid sequences thereof, vectors comprising said nucleic acid sequences and cells transformed with such vectors.

L'invention concerne des compositions de vaccins comprenant un matériel antigénique de péroxirédoxine et/ou .beta.-tubuline, de préférence, d'origine Fasciola ou Dicrocoelium. Ces compositions permettent de combattre une infection parasitaire d'helminthes chez un mammifère. L'invention a aussi pour objet des séquences nucléotidiques qui codent les molécules de péroxirédoxine et/ou .beta.-tubuline et les séquences nucléotidiques de ces dernières, ainsi que des vecteurs comprenant ces séquences nucléotidiques et des cellules transformées par ces vecteurs.

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