Non-toxic mucosal adjuvant

Details Non-toxic mucosal adjuvant Non-toxic mucosal adjuvant

A - Human Necessities

61

K

A61K 39/39 (2006.01)

Patent

CA 2179771

A non-toxic mucosal adjuvant is provided which may be admixed with further antigens to provide a vaccine administrable to mucosal surfaces in organisms including man. Preferably, the non-toxic mucosal adjuvant is a detoxified mutant of a bacterial ADP-ribosylating toxin, optionally comprising one or more amino acid additions, deletions or substitutions.

L'invention se rapporte à un adjuvant non toxique pour les muqueuses qui peut être mélangé à d'autres antigènes afin de produire un vaccin pouvant être administré sur les muqueuses d'organismes, y compris l'homme. De préférence, l'adjuvant non toxique pour les muqueuses est un mutant détoxiqué d'une toxine bactérienne ribosylant l'ADP, éventuellement comprenant au moins une addition, une délétion ou substitution d'acides aminés.

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