Methods for increasing the proliferation of b cells

Details Methods for increasing the proliferation of b cells Methods for increasing the proliferation of b cells

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01)

Patent

CA 2517140

Disclosed herein are methods of increasing the proliferation of non- tumorigenic B cells. The methods involve administering PCDGF and optionally other B cells stimulators (e.g., IgM, LPS) to B cells resulting in an increase in B cell proliferation. The methods of the invention can be used, for example, to establish B cells lines, to sort B cells from a mixed population of cells, or to activate resting B cells.

L'invention porte sur des procédés visant à augmenter la prolifération des lymphocytes B non tumorigènes, ainsi que sur des procédés consistant à administrer PCDGF et éventuellement d'autres stimulateurs des lymphocytes B (tels que IgM, LPS) à des lymphocytes B, entraînant une augmentation de la prolifération de ces lymphocytes B. Les procédés de cette invention peuvent être utilisés, par exemple, pour établir des lignées de lymphocytes B, pour trier les lymphocytes B faisant partie d'une population mixtes de cellules ou pour activer les lymphocytes B restants.

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