Toll-like receptor (tlr) stimulation for ocular angiogenesis...

Details Toll-like receptor (tlr) stimulation for ocular angiogenesis... Toll-like receptor (tlr) stimulation for ocular angiogenesis...

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61K 31/4745 (2006.01) A61K 31/513 (2006.01) A61K 31/708 (2006.01) A61K 31/713 (2006.01) A61P 27/02 (2006.01) A61P 27/06 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2652349

Provided are methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization. Administration of stimulators of the TLR3 or TLR7 receptors, Trif or of IL-10 or IL-12 inhibits ocular angiogenesis. Furthermore, all siRNAs (both targeted and non-targeted) can inhibit ocular angiogenesis.

L'invention concerne des procédés et des compositions destinés à traiter ou à prévenir l'angiogenèse oculaire et la néovascularisation. L'administration de stimulateurs des récepteurs TLR3 ou TLR7, de Trif, de l'IL-10 ou de l'IL-12 permet d'inhiber l'angiogenèse oculaire. Par ailleurs, tous les ARNsi (ciblés et non ciblés) peuvent inhiber l'angiogenèse oculaire.

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