Dsp-11 dual-specificity map kinase phosphatase

Details Dsp-11 dual-specificity map kinase phosphatase Dsp-11 dual-specificity map kinase phosphatase

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) C12N 15/11 (2006.01) C12Q 1/42 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2379983

Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-11, and polypeptide variants thereof that stimulate dephosphorylation of DSP-11 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-11 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

L'invention concerne des compositions et des procédés destinés au traitement de conditions liées à la prolifération, différenciation et survie cellulaires. Notamment, elle a trait à la phosphatase à spécificité duale DSP-11 et à des variants de polypeptides correspondants qui stimulent la déphosphorylation de substrats DSP-11. Les polypeptides peuvent être utilisés, par exemple, pour identifier des anticorps et d'autres agents qui inhibent l'activité DSP-11. Les polypeptides et les agents peuvent être utilisés pour moduler la prolifération, la différenciation et la survie cellulaires.

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