Microbial reduction of an acetoxyketone

Details Microbial reduction of an acetoxyketone Microbial reduction of an acetoxyketone

C - Chemistry, Metallurgy

12

P

C12P 17/12 (2006.01) C07D 241/10 (2006.01)

Patent

CA 2682304

The present invention relates to biocatalytic asymmetric reduction for the preparation of 2-amino- [5-( l-hydroxy-2-hydroxy or halogen-ethyl) ] -pyrazine derivatives of the formula (formula I) wherein R is lower alkylcarbonyl or an amino protecting group and R1 is hydroxy or halogen. The compounds are key intermediates in the manufacture of a glucokinase activator.

L'invention concerne une réduction biocatalytique asymétrique destinée à la préparation de dérivés de 2-amino- [5-( l-hydroxy-2-hydroxy ou halogène-éthyl) ] -pyrazine de la formule (formule I), dans laquelle R est alkylcarbonyle inférieur ou un groupe protecteur d'amine et R1 est hydroxy ou halogène. Les composés de l'invention sont des intermédiaires clés dans la fabrication d'un activateur de la glucokinase.

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