Compositions and methods for treating and diagnosing cancers

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/18 (2006.01) A61K 38/08 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 7/08 (2006.01) G01N 33/53 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2683137

Disclosed are peptides, polypeptides, antibodies, small molecules, and methods for their use for imaging a neoplasm and for treating cancer in a mammal. The methods include administering one or more of the agents of the invention to a mammal, e.g., a human; the peptides, polypeptides, antibodies, and small molecules, which specifically bind to neoplastic cells, can be labeled with a radioactive label or a therapeutic label, e.g., a cytotoxic agent.

L'invention concerne des peptides, des polypeptides, des anticorps, des petites molécules, ainsi que des méthodes d'utilisation de ceux-ci pour l'imagerie d'un néoplasme et pour le traitement de cancers chez un mammifère. Les méthodes consistent à administrer un ou plusieurs des agents de l'invention à un mammifère, par ex., un être humain; les peptides, polypeptides, anticorps et petites molécules, qui se lient spécifiquement à des cellules néoplasiques, peuvent être marqués à l'aide d'un marqueur radioactif ou d'un marqueur thérapeutique, par ex., un agent cytotoxique.

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