Thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone...

Details Thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone... Thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2721738

In its many embodiments, the present invention provides provides certain thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidone compounds, including compounds (or tautomers or a pharmaceutically acceptable salts thereof) having the structural Formula (III): wherein R2, R3, R4, R5, R6, R7, R8, and R9 are each selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds, and methods for their preparation and use in treating pathologies associated with amyloid beta (A.BETA.) protein, including Alzheimer's Disease, are also disclosed.

Dans ses nombreux modes de réalisation, la présente invention concerne certains composés de 2-imino-3-méthyl-pyrrolo pyrimidone substitués par thiophényle, notamment des composés (or des tautomères ou un sel pharmaceutiquement acceptable de ceux-ci) de formule (III) dans laquelle R2, R3, R4, R5, R6, R7, R8 et R9 sont sélectionnés indépendamment et sont tels que définis dans la description. Linvention concerne également des compositions pharmaceutiques contenant au moins un de ces composés, ainsi que des méthodes de préparation et dutilisation de ces compositions dans le traitement de pathologies associées à la protéine amyloïde bêta (Aß), notamment la maladie dAlzheimer.

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