A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) C12N 5/0793 (2010.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61P 25/00 (2006.01) C12N 11/04 (2006.01)
Patent
CA 2590336
The present invention relates to methods and compositions for altering (e.g., augmenting or stimulating) differentiation and growth of cells (e.g., neural progenitor cells and neurons). In particular, the present invention relates to compositions comprising one or more self-assembling peptide amphiphiles (e.g., in solution or that generate (e.g., self-assemble into) nanofibers (e.g., that are able to encapsulate cells and promote cellular differentiation (e.g., neurite development))) and methods of using the same. Compositions and methods of the present invention find use in research, clinical (e.g., therapeutic) and diagnostic settings.
La présente invention concerne des méthodes et des compositions servant à altérer (par ex., augmenter ou stimuler) la différenciation et la croissance des cellules (par ex., des cellules progénitrices neurales et des neurones). Notamment, cette invention a pour objet des compositions renfermant une ou plusieurs molécules amphiphiles peptidiques à auto-assemblage (par ex., dans une solution ou qui engendrent (par ex., s'auto-assemblent dans) des nanofibres (par ex., qui sont capables d'encapsuler des cellules et de favoriser la différenciation cellulaire (par ex., le développement de neurites))). Ladite invention a également trait à des méthodes d'utilisation associées, à des compositions et à des méthodes utilisées dans la recherche, les installations cliniques (par ex., thérapeutiques) et diagnostiques.
Kessler John A.
Stupp Sam I.
Bennett Jones Llp
Northwestern University
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