Pharmaceutical compositions comprising hydroxylansoprazole...

A - Human Necessities – 61 – K

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A61K 31/4439 (2006.01) A61K 9/28 (2006.01) A61K 9/40 (2006.01) A61P 17/02 (2006.01) A61P 17/06 (2006.01)

Patent

CA 2337886

Methods and compositions are disclosed utilizing hydroxylansoprazole for the treatment of ulcers in humans. Hydroxylansoprazole exhibits a lessened liability toward drug-drug interactions than lansoprazole and a more predictable dosing regimen than lansoprazole. Hydroxylansoprazole is also useful for the treatment of gastroesophageal reflux and other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.

On décrit des procédés et des compositions dans lesquels on utilise de l'hydroxylansoprazole pour traiter les ulcères chez l'homme. L'hydroxylansoprazole possède un plus faible potentiel pour les interactions médicament-médicament que le lansoprazole et correspond à un schéma posologique plus prévisible que le lansoprazole. L'hydroxylansoprazole est également utile pour traiter le reflux gastro-oesophagien et d'autres conditions liées à l'hypersécrétion gastrique telles que le syndrome de Zollimger-Ellison.

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